Protein aggregation - Latest research and news | Nature
WEBSep 16, 2024 · Protein aggregation is the process by which misfolded proteins adopt a conformation that cause its polymerization into aggregates and organized fibrils.
Groundbreaking Study Challenges Key Theory on Parkinson’s …
WEBSep 16, 2024 · In the case of neurodegenerative diseases characterized by the formation of protein aggregates, such as Alzheimer’s and Parkinson’s, it has been supposed that protein droplets are a precursor to pathological protein aggregation. The idea behind this theory is that droplets can concentrate certain proteins, and this could push them to the ...
Protein aggregation: A new frontier in age-related disease …
WEBJun 17, 2024 · While the molecular mechanisms are widely debated and an important aspect of basic research, scientists know that aggregates formed from IDPs tend to accumulate in many long-lived cells - such as...
Researchers propose a new way to measure aging and disease risk …
WEBJun 17, 2024 · If developed further into a sensitive diagnostic test, a protein aggregation clock could be extremely useful. Firstly, doctors could use it to help diagnose age-related diseases at very early...
Promising Novel Therapies Targeting Tau Aggregates
WEB19 hours ago · Tau and amyloid are the two main proteins that misfold and accumulate into aggregates in the brains of people with Alzheimer’s disease. Amyloid aggregates accumulate in the spaces between neurons so can be targeted with drugs such as monoclonal antibodies. Tau ‘tangles’, on the other …
Treating diseases by eliminating protein aggregation in the brain ...
WEBJan 18, 2024 · Purdue University researcher Jessica Sonia Fortin and her collaborators are creating multiple patent-pending compounds to treat Alzheimer’s disease, Parkinson’s disease and Type 2 diabetes. The compounds inhibit protein aggregation in the brain and pancreas associated with the diseases. (iStock illustration provided/Jolygon) January 18 ...
Mechanisms and pathology of protein misfolding and aggregation
WEBSep 8, 2023 · Here, we review the current understanding of how intrinsic protein conformational propensities are modulated by physiological and pathological interactions in the cell to shape protein...
Researchers discover tissue-specific protection against protein aggregation
WEBSep 14, 2023 · Their experiments revealed a tissue-specific mechanism they've called "SAPA: safeguard against protein aggregation" which kicks in when other protein quality control mechanisms are defective.
Protein aggregation - Nature
WEBDec 6, 2023 · Proteins prone to aggregation in yeast are imported into mitochondria under stress conditions, suggesting that mitochondrial import and proteolysis may help to disaggregate proteins in the...
Visualizing the Multistep Process of Protein Aggregation in Live …
WEBJan 18, 2022 · Protein aggregation is a biological phenomenon in which aberrantly processed or mutant proteins misfold and assemble into a variety of insoluble aggregates. Decades of studies have delineated the structure, interaction, and activity of proteins in either their natively folded structures or insoluble aggregates such as amyloid fibrils.